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Ro5-4864, commonly known as 4′-chlorodiazepam, is a new benzodiazepine derivative of diazepam. However, unlike most benzodiazepine derivatives,ย lacks affinity for GABAA receptors and does not produce conventional benzodiazepine effects, instead acting as a sedative while also being convulsant and anxiogenic. Shown to be a strong agonist of the “peripheral benzodiazepine receptor,” which was later termed mitochondrial translocator protein 18kDa (TSPO). In vitro and animal research indicate the possibility of analgesic, antidepressant, cardioprotective, and anti-cancer properties.
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